Boltzmann machines as generalized hopfield networks: A review of recent results and outlooks

The Hopfield model and the Boltzmann machine are among the most popular examples of neural networks. The latter, widely used for classification and feature detection, is able to efficiently learn a generative model from observed data and constitutes the benchmark for statistical learning. The former, designed to mimic the retrieval phase of an artificial associative memory lays in between two paradigmatic statistical mechanics models, namely the Curie-Weiss and the Sherrington-Kirkpatrick, which are recovered as the limiting cases of, respectively, one and many stored memories. Interestingly, the Boltzmann machine and the Hopfield network, if considered to be two cognitive processes (learning and information retrieval), are nothing more than two sides of the same coin. In fact, it is possible to exactly map the one into the other. We will inspect such an equivalence retracing the most representative steps of the research in this field

Nurses and the acceptance of innovations in technology-intensive contexts: the need for tailored management strategies

BACKGROUND: Several technological innovations have been introduced in healthcare over the years, and their implementation proved crucial in addressing challenges of modern health. Healthcare workers have frequently been called upon to become familiar with technological innovations that pervade every aspect of their profession, changing their working schedule, habits, and daily actions. PURPOSE: An in-depth analysis of the paths towards the acceptance and use of technology may facilitate the crafting and adoption of specific personnel policies taking into consideration definite levers, which appear to be different in relation to the age of nurses. APPROACH: The strength of this study is the application of UTAUT model to analyse the acceptance of innovations by nurses in technology-intensive healthcare contexts. Multidimensional Item Response Theory is applied to identify the main dimensions characterizing the UTAUT model. Paths are tested through two stage regression models and validated using a SEM covariance analysis. RESULTS: The age is a moderator for the social influence: social influence, or peer opinion, matters more for young nurse. CONCLUSION: The use of MIRT to identify the most important items for each construct of UTAUT model and an in-depth path analysis helps to identify which factors should be considered a leverage to foster nurses' acceptance and intention to use new technologies (o technology-intensive devices). PRACTICAL IMPLICATIONS: Young nurses may benefit from the structuring of shifts with the most passionate colleagues (thus exploiting the social influence), the participation in ad hoc training courses (thus exploiting the facilitating conditions), while other nurses could benefit from policies that rely on the stressing of the perception of their expectations or the downsizing of their expectancy of the effort in using new technologies

DBS-Based Eutectogels: Organized Vessels to Perform the Michael Addition Reaction**

Supramolecular eutectogels were obtained from the gelation of 1,3 : 2,4-dibenzylidene-D-sorbitol (DBS) in cholinium chloride-based deep eutectic solvents (DES), differing for the nature of the hydrogen bond donor. Ethylene glycol, diethylene glycol, triethylene glycol, glycerol and urea were tested. Soft materials were fully characterized, determining critical gelation concentration, gel-sol transition temperatures and mechanical properties. Furthermore, to have information about the organization of the gelator in the tridimensional network, resonance light scattering, circular dichroism and microscopy investigations were performed. Eutectogels were used as organized “vessels” to perform the L-proline catalyzed Michael addition reaction. The probe reaction was carried out in gel phase and in DES solution. Data collected shed light on the effect that gel microenvironment exerts on the outcome of the reaction. In general, gel phases allowed having comparable or even better results than the ones collected in DES solution, with better results obtained in soft materials with the highest organization, as accounted for by the presence of larger aggregates and the occurrence of stronger intermolecular interactions. In turn, this accounts also for the effect of substrates structure that indicates that better yields could be obtained in the presence of more flexible nucleophile and dienones, having more extended π-surface

Catalysis in Supramolecular Systems: the Case of Gel Phases

Supramolecular gels are a fascinating class of materials, originated by the self-assembly of low molecular weight molecules. Underpinned by non-covalent interactions, they find application in a diverse range of fields. Among these, supramolecular gels can be considered as organized, non-conventional reaction media, able to influence reactivity in a radically different way, compared with what happens in solution. This short review will focus on this aspect, covering literature from 2010 onwards, addressing the application of supramolecular gels as reaction media. In particular, in the first section we explore organocatalytic reactions in gel phase, with wide synthetic relevance, such as aldol and Mannich reactions as well as Friedel Crafts or ester hydrolysis processes. Subsequently, focus is laid on metal-catalysed reactions, among which relevance is given to widely used reactions like cross-coupling and click reactions. Then, the final sections describe the use of supramolecular gels as reaction media for photo- and biocatalysed processes

Insights about the ability of folate based supramolecular gels to act as targeted therapeutic agents

With the aim to obtain targeted chemotherapeutic agents, imidazolium and ammonium-based folate salts were synthesized. Their photophysical behavior was investigated both in buffer and buffer/DMSO solution as well as in solid phase, performing UV-vis and fluorescence investigations. Properties of the aggregates were also analyzed by dynamic light scattering. Gelation ability of the salts was analyzed in biocompatible solvents, and gel phases obtained were characterized by determining critical gelation concentrations and gel-solution transition temperatures. Insights about gelator interactions in the tridimensional network were also gained performing ATR-FTIR investigation. Properties of soft materials were further analyzed performing rheology measurements, scanning electron microscopy, fluorescence and resonance light scattering investigations. Antiproliferative activity of organic salts was tested towards two breast cancer cell lines, expressing different levels of folate receptor, namely MDA-MB-231 and MCF-7, and a normal epithelial cell line, like h-TER T-RPE-1, by using MTT assay. Dichlodihydrofluorescein acetate test was performed to verify the role of oxidative stress in cell death. Finally, antiproliferative activity was also evaluated in gel phase, to verify if salts were able to retain biological activity also after the entrapment in the gelatinous network. Results collected evidence that folate based organic salts were able to behave as targeted chemotherapeutic agents both in solution and gel phase, showing uptake mechanism and selectivity indexes that depend on both cancer cell line nature and salt structure

El «ángulo muerto» del Derecho Internacional: las empresas transnacionales y sus cadenas de suministro

La creación de normas vinculantes y la búsqueda de recursos efectivos para las víctimas de graves violaciones de derechos humanos cometidas por empresas transnacionales, han sido y son, los objetivos de la lucha más difícil a la que se enfrentan los defensores de los derechos humanos en todo el mundo. A nivel internacional, muchos han sido los intentos de creación de normas vinculantes sobre la protección de los derechos humanos en el ámbito de las empresas. El “ángulo muerto” del derecho internacional hace referencia al hecho de que en la actualidad no existen normas de hard law capaces de responsabilizar a las corporaciones internacionales por los graves ilícitos internacionales perpetrados extraterritorialmente en sus cadenas de suministro. La finalidad de este trabajo es tomar conciencia de este problema y al mismo tiempo evaluar mecanismos, estrategias y acciones desde la perspectiva civil, para garantizar el derecho de acceso a la justicia, y con ello, colmar en parte este “ángulo muerto” del derecho internacional.The implementation of binding norms and the search for effective remedies for victims of serious human rights violations committed by transnational corporations have been and continue to be the objectives of the most difficult struggle that human rights defenders are facing all over the world. At the international level, many attempts have been made to create binding rules on human rights and business. The “dead angle” of international law refers to the fact that actually there are no hard law norms capable of holding corporations responsible for the serious internationally wrongful perpetrated extraterritorially by their supply chains. The purpose of this work is to become aware of this problem, while evaluating other mechanisms, strategies and actions from a civil perspective, to guarantee the right of access to justice in an attempt to fill partially this “dead angle” of international law

Regional Interest Rate Pass-Through in Italy

Regional interest rate pass-through in Italy, Regional Studies. This paper estimates the pass-through and speed of adjustment of Italian regional interest rates to changes in the money market rate for the period 1998Q1–2009Q4. The main findings suggest that the mark-ups for the lending rates that banks charge are generally higher in the South than in the North. Moreover, the empirical results indicate that the pass-through tends to be longer in Southern regions. Furthermore, little support is found for the hypothesis that regional banks react asymmetrically when adjusting their loan rates when these are above or below equilibrium levels, but some evidence supporting an upward rigidity in the regional deposit rates is detected

Realization of the farad from the dc quantum Hall effect with digitally-assisted impedance bridges

A new traceability chain for the derivation of the farad from dc quantum Hall effect has been implemented at INRIM. Main components of the chain are two new coaxial transformer bridges: a resistance ratio bridge, and a quadrature bridge, both operating at 1541 Hz. The bridges are energized and controlled with a polyphase direct-digital-synthesizer, which permits to achieve both main and auxiliary equilibria in an automated way; the bridges and do not include any variable inductive divider or variable impedance box. The relative uncertainty in the realization of the farad, at the level of 1000 pF, is estimated to be 64E-9. A first verification of the realization is given by a comparison with the maintained national capacitance standard, where an agreement between measurements within their relative combined uncertainty of 420E-9 is obtained.Comment: 15 pages, 11 figures, 3 table

Diet supplementation, probiotics, and nutraceuticals in SARS-CoV-2 infection. A scoping review

The severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) global pandemic is a devastating event that is causing thousands of victims every day around the world. One of the main reasons of the great impact of coronavirus disease 2019 (COVID-19) on society is its unexpected spread, which has not allowed an adequate preparation. The scientific community is fighting against time for the production of a vaccine, but it is difficult to place a safe and effective product on the market as fast as the virus is spreading. Similarly, for drugs that can directly interfere with viral pathways, their production times are long, despite the great efforts made. For these reasons, we analyzed the possible role of non-pharmacological substances such as supplements, probiotics, and nutraceuticals in reducing the risk of Sars-CoV-2 infection or mitigating the symptoms of COVID-19. These substances could have numerous advantages in the current circumstances, are generally easily available, and have negligible side effects if administered at the already used and tested dosages. Large scientific evidence supports the benefits that some bacterial and molecular products may exert on the immune response to respiratory viruses. These could also have a regulatory role in systemic inflammation or endothelial damage, which are two crucial aspects of COVID-19. However, there are no specific data available, and rigorous clinical trials should be conducted to confirm the putative benefits of diet supplementation, probiotics, and nutraceuticals in the current pandemic